The link between obesity and osteoporosis-two major public-health problems, has become central to bone research in recent years, ever since leptin was identified as a regulator ofboth appetite and bone density. In contrast, the effect of leptin on skeletal development and bone elongation, another anticipated link between metabolic status and skeletal growth rate, has been less recognized. Here we summarize the existing data on leptin s effects on bone elongation-its central effect through the GHRH -GH -IG F-1 axis on pubertal growth and its peripheral, direct roles on growth-plate chondrocytes, including the expression of leptin and its receptor and its effect on each part of the endochondral ossification process. We conclude that the data are still incomplete, as they give only a partial view of leptin srole in bone development and growth.
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© 2009 by Taylor and Francis Group, LLC.