The Role of MicroRNAs in the control of innate immune response in cancer

Simon Jasinski-Bergner, Ofer Mandelboim, Barbara Seliger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

58 Scopus citations

Abstract

Ligands for receptors of natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon viral infection and neoplastic transformation, thereby preventing virusinfected or malignant-transformed cells from elimination by immune effector cells. Recently, it has been shown that ligands of both NK and CD8+ T cells are regulated by a number of cellular and/or viral microRNAs (miRs). These miRs are involved in shaping the antiviral and/or antitumoral immune responses as well as neoplastic growth properties. This review summarizes the expression pattern and function of miRs directed against selected NK and T cell receptor ligands, their putative role in shaping immune surveillance and tumorigenicity, and their clinical relevance. In addition, the potential role of RNA-binding proteins in the posttranscriptional gene regulation of these ligands will be discussed.

Original languageAmerican English
JournalJournal of the National Cancer Institute
Volume106
Issue number10
DOIs
StatePublished - 1 Oct 2014

Bibliographical note

Publisher Copyright:
© The Author 2014.

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