TY - JOUR
T1 - The Role of MicroRNAs in the control of innate immune response in cancer
AU - Jasinski-Bergner, Simon
AU - Mandelboim, Ofer
AU - Seliger, Barbara
N1 - Publisher Copyright:
© The Author 2014.
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Ligands for receptors of natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon viral infection and neoplastic transformation, thereby preventing virusinfected or malignant-transformed cells from elimination by immune effector cells. Recently, it has been shown that ligands of both NK and CD8+ T cells are regulated by a number of cellular and/or viral microRNAs (miRs). These miRs are involved in shaping the antiviral and/or antitumoral immune responses as well as neoplastic growth properties. This review summarizes the expression pattern and function of miRs directed against selected NK and T cell receptor ligands, their putative role in shaping immune surveillance and tumorigenicity, and their clinical relevance. In addition, the potential role of RNA-binding proteins in the posttranscriptional gene regulation of these ligands will be discussed.
AB - Ligands for receptors of natural killer (NK) cells and CD8+ cytotoxic T lymphocytes (CTL), such as the inhibitory nonclassical HLA-G, the activating stress-induced major histocompatibility complex class I-related antigens MICA and MICB, and/or the UL16-binding proteins (ULBPs), are often aberrantly expressed upon viral infection and neoplastic transformation, thereby preventing virusinfected or malignant-transformed cells from elimination by immune effector cells. Recently, it has been shown that ligands of both NK and CD8+ T cells are regulated by a number of cellular and/or viral microRNAs (miRs). These miRs are involved in shaping the antiviral and/or antitumoral immune responses as well as neoplastic growth properties. This review summarizes the expression pattern and function of miRs directed against selected NK and T cell receptor ligands, their putative role in shaping immune surveillance and tumorigenicity, and their clinical relevance. In addition, the potential role of RNA-binding proteins in the posttranscriptional gene regulation of these ligands will be discussed.
UR - http://www.scopus.com/inward/record.url?scp=84984999084&partnerID=8YFLogxK
U2 - 10.1093/jnci/dju257
DO - 10.1093/jnci/dju257
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C2 - 25217579
AN - SCOPUS:84984999084
SN - 0027-8874
VL - 106
JO - Journal of the National Cancer Institute
JF - Journal of the National Cancer Institute
IS - 10
ER -
