The role of Na+ in NG108 15 opiate receptor function

Arthur J. Blume; David Lichtshtein; Gloria Boone

doi:10.1016/B978-0-08-025488-3.50067-2

The role of Na+ in NG108 15 opiate receptor function

Arthur J. Blume
, David Lichtshtein
, Gloria Boone

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Summary Sodium and GTP are important physiological effectors of the opiate receptors in NG108-15 neuroblastoma x glioma hybrid cells. With membrane preparations, Na+ and guanine nucleotides regulate opiate binding and are required for opiate inhibition of adenylate cyclase. With intact viable cells, [Na+]out is required for opiate control over intracellular cAMP concentrations. The data are discussed in terms of a model in which separate membrane components, through their association with the opiate receptor, render it physiologically active and at the same time Na+ - and nucleotide-sensitive.

Original language	American English
Title of host publication	Endogenous and Exogenous Opiate Agonists and Antagonists
Editors	E. Leong Way
Publisher	Pergamon
Pages	251-254
Number of pages	4
ISBN (Print)	978-0-08-025488-3
DOIs	https://doi.org/10.1016/B978-0-08-025488-3.50067-2
State	Published - 1980

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/B978-0-08-025488-3.50067-2

https://www.sciencedirect.com/science/article/pii/B9780080254883500672

Cite this

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title = "The role of Na+ in NG108 15 opiate receptor function",

abstract = "Summary Sodium and GTP are important physiological effectors of the opiate receptors in NG108-15 neuroblastoma x glioma hybrid cells. With membrane preparations, Na+ and guanine nucleotides regulate opiate binding and are required for opiate inhibition of adenylate cyclase. With intact viable cells, [Na+]out is required for opiate control over intracellular cAMP concentrations. The data are discussed in terms of a model in which separate membrane components, through their association with the opiate receptor, render it physiologically active and at the same time Na+ - and nucleotide-sensitive.",

author = "Blume, \{Arthur J.\} and David Lichtshtein and Gloria Boone",

year = "1980",

doi = "10.1016/B978-0-08-025488-3.50067-2",

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T1 - The role of Na+ in NG108 15 opiate receptor function

AU - Blume, Arthur J.

AU - Lichtshtein, David

AU - Boone, Gloria

PY - 1980

Y1 - 1980

N2 - Summary Sodium and GTP are important physiological effectors of the opiate receptors in NG108-15 neuroblastoma x glioma hybrid cells. With membrane preparations, Na+ and guanine nucleotides regulate opiate binding and are required for opiate inhibition of adenylate cyclase. With intact viable cells, [Na+]out is required for opiate control over intracellular cAMP concentrations. The data are discussed in terms of a model in which separate membrane components, through their association with the opiate receptor, render it physiologically active and at the same time Na+ - and nucleotide-sensitive.

AB - Summary Sodium and GTP are important physiological effectors of the opiate receptors in NG108-15 neuroblastoma x glioma hybrid cells. With membrane preparations, Na+ and guanine nucleotides regulate opiate binding and are required for opiate inhibition of adenylate cyclase. With intact viable cells, [Na+]out is required for opiate control over intracellular cAMP concentrations. The data are discussed in terms of a model in which separate membrane components, through their association with the opiate receptor, render it physiologically active and at the same time Na+ - and nucleotide-sensitive.

U2 - 10.1016/B978-0-08-025488-3.50067-2

DO - 10.1016/B978-0-08-025488-3.50067-2

M3 - Chapter

SN - 978-0-08-025488-3

SP - 251

EP - 254

BT - Endogenous and Exogenous Opiate Agonists and Antagonists

A2 - Way, E. Leong

PB - Pergamon

ER -

The role of Na+ in NG108 15 opiate receptor function

Abstract

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