Abstract
The effect of indomethacin on the appearance and phagocytic activity of bone marrow-derived macrophages was examined. Although there was an increase in the percentage of macrophages in the indomethacin-treated cultures, a significant decrease in their capacity to phagocytose opsonized sheep erythrocytes was observed. Addition of prostaglandins (PG) PGE2 and PGF2α to the cultures prevented the effects of the indomethacin. Addition of PG to the bone marrow cells after 5 days of culture in the presence of indomethacin did not restore the phagocytic activity. However, addition of PG to mature bone marrow-derived macrophages treated with indomethacin restored their phagocytic activity. Thus, we propose that the results observed were due to the effect of indomethacin on macrophage development.
| Original language | English |
|---|---|
| Pages (from-to) | 377-382 |
| Number of pages | 6 |
| Journal | RES Journal of the Reticuloendothelial Society |
| Volume | 27 |
| Issue number | 4 |
| State | Published - 1980 |
| Externally published | Yes |