The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis

Mona Dvir-Ginzberg*, Ali Mobasheri, Ashok Kumar

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations

Abstract

The past decade has witnessed many advances in the understanding of sirtuin biology and related regulatory circuits supporting the capacity of these proteins to serve as energy-sensing molecules that contribute to healthspan in various tissues, including articular cartilage. Hence, there has been a significant increase in new investigations that aim to elucidate the mechanisms of sirtuin function and their roles in cartilage biology, skeletal development, and pathologies such as osteoarthritis (OA), rheumatoid arthritis (RA), and intervertebral disc degeneration (IVD). The majority of the work carried out to date has focused on SIRT1, although SIRT6 has more recently become a focus of some investigations. In vivo work with transgenic mice has shown that Sirt1 and Sirt6 are essential for maintaining cartilage homeostasis and that the use of sirtuin-activating molecules such as resveratrol may have beneficial effects on cartilage anabolism. Current thinking is that SIRT1 exerts positive effects on cartilage by encouraging chondrocyte survival, especially under stress conditions, which may provide a mechanism supporting the use of sirtuin small-molecule activators (STACS) for future therapeutic interventions in OA and other degenerative pathologies of joints, especially those that involve articular cartilage.

Original languageAmerican English
Article number43
JournalCurrent Rheumatology Reports
Volume18
Issue number7
DOIs
StatePublished - 1 Jul 2016

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York.

Keywords

  • Cartilage
  • Degeneration
  • Intervertebral disc (IVD)
  • Osteoarthritis (OA)
  • Rheumatoid arthritis
  • SIRT1
  • Sirtuin

Fingerprint

Dive into the research topics of 'The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis'. Together they form a unique fingerprint.

Cite this