The role of sweat in the composition of skin microbiome: lessons learned from patients with congenital insensitivity to pain with anhidrosis

M. Brandwein, A. Horev, B. Bogen, G. Fuks, A. Israel, G. Shalom, V. Pinsk, D. Steinberg, Z. Bentwich, N. Shental*, S. Meshner

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

3 Scopus citations
Original languageAmerican English
Pages (from-to)e183-e186
JournalJournal of the European Academy of Dermatology and Venereology
Issue number4
StatePublished - 1 Apr 2020

Bibliographical note

Funding Information:
Funding: This study was supported by the Israeli Ministry of Science and Technology (Grant 3‐11174). Michael Brandwein is a recipient of the Kaete Klausner Fellowship. The funding organizations were not involved in study design, data collection, data analysis or any other stage of the research.

Funding Information:
To the Editor, Congenital insensitivity to pain with anhidrosis (CIPA) is an extremely rare autosomal recessive disorder with only several hundred cases reported worldwide. CIPA results in a number of rare symptoms, including anhidrosis and recurring skin infections, oftentimes caused by Staphylococci spp. In an effort to shed light on the contribution of sweat in shaping the composition of the skin microbiome in healthy individuals, as well as to characterize the skin microbiome in this condition, we profiled the skin microbiome of individuals with CIPA (36 samples from 12 CIPA patients) on the forehead, glabella and antecubital fossa and compared the skin microbiome composition to that of healthy volunteers.

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