TY - JOUR
T1 - The roles of trp and calcium in regulating photoreceptor function in Drosophila
AU - Minke, Baruch
AU - Selinger, Zvi
PY - 1996/8
Y1 - 1996/8
N2 - Invertebrate photoreceptors use the ubiquitous inositol-lipid signaling pathway for phototransduction. This pathway depends on Ca2+ release from internal stores and on Ca2+ entry via light-activated channels to replenish the loss of Ca2+ in those stores. The Drosophila transient receptor potential (TRP) protein is essential for the high Ca2+ permeability and other biophysical properties of these light-activated channels, which affect both excitation and adaptation in photoreceptor cells. Physiological and heterologous expression studies indicate that TRP is a putative subunit of a surface membrane channel that can be activated by depletion of internal Ca2+ stores. Furthermore, trp is an archetypal member of a multigene family whose products share a structure that is highly conserved throughout evolution, from worms to humans.
AB - Invertebrate photoreceptors use the ubiquitous inositol-lipid signaling pathway for phototransduction. This pathway depends on Ca2+ release from internal stores and on Ca2+ entry via light-activated channels to replenish the loss of Ca2+ in those stores. The Drosophila transient receptor potential (TRP) protein is essential for the high Ca2+ permeability and other biophysical properties of these light-activated channels, which affect both excitation and adaptation in photoreceptor cells. Physiological and heterologous expression studies indicate that TRP is a putative subunit of a surface membrane channel that can be activated by depletion of internal Ca2+ stores. Furthermore, trp is an archetypal member of a multigene family whose products share a structure that is highly conserved throughout evolution, from worms to humans.
UR - http://www.scopus.com/inward/record.url?scp=0030218120&partnerID=8YFLogxK
U2 - 10.1016/S0959-4388(96)80050-X
DO - 10.1016/S0959-4388(96)80050-X
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C2 - 8794093
AN - SCOPUS:0030218120
SN - 0959-4388
VL - 6
SP - 459
EP - 466
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 4
ER -