TY - JOUR
T1 - The significance of sweat Cl/Na ratio in patients with borderline sweat test
AU - Augarten, Arie
AU - Hacham, Shoshana
AU - Kerem, Eitan
AU - Kerem, Bat Sheva
AU - Szeinberg, Amir
AU - Laufer, Joseph
AU - Doolman, Ram
AU - Altshuler, Ruth
AU - Blau, Hana
AU - Bentur, Lea
AU - Gazit, Ephraim
AU - Katznelson, Daniel
AU - Yahav, Yaacov
PY - 1995/12
Y1 - 1995/12
N2 - Recently a few cystic fibrosis (CF) patients with borderline or normal sweat tests have been reported. These patients present a diagnostic challenge. We aimed to study the sweat CINa ratio in cystic fibrosis patients and to assess whether this ratio could be used as a diagnostic criteria. The mean sweat CINa ratio of 3 groups was compared: Group A: 71 CF patients carrying 2 mutations known to be associated with severe disease presentation (ΔF508, W1282X, G542X, N1303K, 1717‐1G → A). Group B: 10 compound heterozygous patients who carry one mutation associated with mild clinical disease (3849 + 10 kb C → T). Group C: 142 normal subjects. Sweat chloride levels higher than those of sodium were found in 96% of patients in Group A as compared to 3% of patients in Group C. In Group B 40% of the patients had sweat chloride levels higher than or equal to sodium levels. The mean Cl/Na ratio of Group A (1.2 ± 0.1) differed significantly from that of Group B (0.94 ± 0.1) and both groups had significant higher mean CINa ratio compared to Group C (0.7 ± 0.4) (P < 0.001). Thus in individuals with a borderline sweat test and a Cl/Na ratio < 1 the diagnosis of CF should be considered. However, a Cl/Na ratio < 1 does not exclude CF, since patients carrying mild mutations may have sweat sodium levels higher than those of chloride. Our findings suggest that the sweat CINa ratio in CF is genetically determined and it may be of help in establishing the diagnosis of CF in patients with a borderline sweat test. Pediatr Pulmonol. 1995; 20:369–371. © 1995 Wiley‐Liss, Inc.
AB - Recently a few cystic fibrosis (CF) patients with borderline or normal sweat tests have been reported. These patients present a diagnostic challenge. We aimed to study the sweat CINa ratio in cystic fibrosis patients and to assess whether this ratio could be used as a diagnostic criteria. The mean sweat CINa ratio of 3 groups was compared: Group A: 71 CF patients carrying 2 mutations known to be associated with severe disease presentation (ΔF508, W1282X, G542X, N1303K, 1717‐1G → A). Group B: 10 compound heterozygous patients who carry one mutation associated with mild clinical disease (3849 + 10 kb C → T). Group C: 142 normal subjects. Sweat chloride levels higher than those of sodium were found in 96% of patients in Group A as compared to 3% of patients in Group C. In Group B 40% of the patients had sweat chloride levels higher than or equal to sodium levels. The mean Cl/Na ratio of Group A (1.2 ± 0.1) differed significantly from that of Group B (0.94 ± 0.1) and both groups had significant higher mean CINa ratio compared to Group C (0.7 ± 0.4) (P < 0.001). Thus in individuals with a borderline sweat test and a Cl/Na ratio < 1 the diagnosis of CF should be considered. However, a Cl/Na ratio < 1 does not exclude CF, since patients carrying mild mutations may have sweat sodium levels higher than those of chloride. Our findings suggest that the sweat CINa ratio in CF is genetically determined and it may be of help in establishing the diagnosis of CF in patients with a borderline sweat test. Pediatr Pulmonol. 1995; 20:369–371. © 1995 Wiley‐Liss, Inc.
KW - Cystic fibrosis
KW - sweat test
UR - http://www.scopus.com/inward/record.url?scp=0028994305&partnerID=8YFLogxK
U2 - 10.1002/ppul.1950200606
DO - 10.1002/ppul.1950200606
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C2 - 8649916
AN - SCOPUS:0028994305
SN - 8755-6863
VL - 20
SP - 369
EP - 371
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
IS - 6
ER -
