The site of action potential initiation in cerebellar Purkinje neurons

Beverley A. Clark, Pablo Monsivais, Tiago Branco, Michael London, Michael Häusser*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations

Abstract

Knowledge of the site of action potential initiation is essential for understanding how synaptic input is converted into neuronal output. Previous studies have shown that the lowest-threshold site for initiation of action potentials is in the axon. Here we use recordings from visualized rat cerebellar Purkinje cell axons to localize the site of initiation to a well-defined anatomical structure: the first node of Ranvier, which normally forms at the first axonal branch point.

Original languageAmerican English
Pages (from-to)137-139
Number of pages3
JournalNature Neuroscience
Volume8
Issue number2
DOIs
StatePublished - Feb 2005
Externally publishedYes

Bibliographical note

Funding Information:
We thank J. T. Davie, J.J.B. Jack, C. Racca and A. Roth for helpful comments; V. Bennett for the ankyrin-G antibody; and A. Gidon, L. Ramakrishnan, E. Rancz, and A. Roth for help with reconstructions and videos. This work was supported by grants from the Wellcome Trust, European Commission, and the Gatsby Foundation. M.L. is a Long-Term Fellow of the Human Frontier Science Program, and T.B. was funded by the Wellcome Trust 4-year PhD Programme in Neuroscience.

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