The STIL protein contains intrinsically disordered regions that mediate its protein-protein interactions

Hadar Amartely, Ahuvit David, Mario Lebendiker, Hadar Benyamini, Shai Izraeli, Assaf Friedler

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

The STIL protein participates in mitosis and malignant transformation by regulating centrosomal duplication. Using biophysical methods we studied the structure and interactions of STIL. We revealed that its central domain is intrinsically disordered and mediates protein-protein interactions of STIL. The intrinsic disorder may provide STIL with the conformational flexibility required for its multitude binding.

Original languageAmerican English
Pages (from-to)5245-5247
Number of pages3
JournalChemical Communications
Volume50
Issue number40
DOIs
StatePublished - 22 Apr 2014

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