Dynamic processes involving macromolecular complexes are essential to cell function. These processes take place over a wide variety of length scales from nanometers to micrometers, and over time scales from nanoseconds to minutes. As a result, information from a variety of different experimental and computational approaches is required. We review the relevant sources of information and introduce a framework for integrating the data to produce representations of dynamic processes.
Bibliographical noteFunding Information:
We thank Yifan Cheng, Friederich Förster, Joerg Gsponer, Avner Schlessinger, and Elizabeth Villa for helpful discussions. KL, JVM, and DSD have been funded by the Clore Foundation Predoctoral Fellowship, Spanish Ministry of Education Postdoctoral Fellowship, and Weizmann Institute Advancing Women in Science Postdoctoral Fellowship, respectively. We also acknowledge support from the Sandler Family Supporting Foundation, NIH/NCRR U54 RR022220, NIH R01 GM083960, NIH PN2 EY016525, NSF IIS 0705196, and Pfizer Inc. And we are grateful for computer hardware gifts from Ron Conway, Mike Homer, Intel, Hewlett-Packard, IBM, and Netapp.