TY - JOUR
T1 - The substrate-facilitated transport of the glucose carrier across the human erythrocyte membrane
AU - Levine, M.
AU - Oxender, D. L.
AU - Stein, W. D.
PY - 1965/9/27
Y1 - 1965/9/27
N2 - 1. 1. The rate of egress of glucose from human red blood cells into saline media either without sugar or containing glucose, galactose, sorbose or fructose has been determined at 25° and for glucose or zero sugar at 0°. 2. 2. From these data, using a simplified form of the theoretical analysis of Regen and Morgan13, it is shown that the rate of movement across the membrane of the substrate-carrier complex is greater than that of the free carrier, that is, the movement of carrier is facilitated by the substrate. 3. 3. A lower limit of 2.8 is derived for the ratio of these rates of movement. 4. 4. Evidence is presented that the aldoses and ketoses share a common carrier.
AB - 1. 1. The rate of egress of glucose from human red blood cells into saline media either without sugar or containing glucose, galactose, sorbose or fructose has been determined at 25° and for glucose or zero sugar at 0°. 2. 2. From these data, using a simplified form of the theoretical analysis of Regen and Morgan13, it is shown that the rate of movement across the membrane of the substrate-carrier complex is greater than that of the free carrier, that is, the movement of carrier is facilitated by the substrate. 3. 3. A lower limit of 2.8 is derived for the ratio of these rates of movement. 4. 4. Evidence is presented that the aldoses and ketoses share a common carrier.
UR - http://www.scopus.com/inward/record.url?scp=0013854716&partnerID=8YFLogxK
U2 - 10.1016/0926-6585(65)90099-3
DO - 10.1016/0926-6585(65)90099-3
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C2 - 5864008
AN - SCOPUS:0013854716
SN - 0926-6585
VL - 109
SP - 151
EP - 163
JO - BBA - Biophysics Including Photosynthesis
JF - BBA - Biophysics Including Photosynthesis
IS - 1
ER -