The suicide brain: A review of postmortem receptor/transporter binding studies

Ruth Gross-Isseroff*, Anat Biegon, Hillary Voet, Abraham Weizman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

69 Scopus citations

Abstract

The present review summarizes the last 15 years of research involving postmortem receptor/transporter binding studies on brains of suicide victims. It is our working hypothesis, on the basis of psychological, behavioral and epidemiological studies, that suicidal behavior is an independent unique behavioral entity with specific neurochemical characteristics. This review tales to test this hypothesis at the level of neurotransmitter receptors by using a different approach to data analysis. We suggest that this statistical approach, involving multivariate analyses, can contribute to the formulation of new hypotheses at the level of molecular biology and genetics. Such studies if undertaken in the future, would help define suicidal behavior as a psycho-neuro-pathological entity.

Original languageEnglish
Pages (from-to)653-661
Number of pages9
JournalNeuroscience and Biobehavioral Reviews
Volume22
Issue number5
DOIs
StatePublished - Sep 1998

Keywords

  • Brain
  • Depression
  • GABA
  • Norepinephrine
  • Opioids
  • Serotonin
  • Suicide

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