The synthesis and secretion of human placental lactogen (hPL) in cultured term placenta

Daniel Weinstein; Hanan Galski; Joseph G. Schenker; Haya Lorberboum; Nathan de Groot; Judith Ilan; Rachel Folman; Abraham A. Hochberg

doi:10.1016/0303-7207(82)90016-8

The synthesis and secretion of human placental lactogen (hPL) in cultured term placenta

Daniel Weinstein^*, Hanan Galski, Joseph G. Schenker, Haya Lorberboum, Nathan de Groot, Judith Ilan, Rachel Folman, Abraham A. Hochberg

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We studied the in vitro synthesis and secretion of hPL by human term placental tissue incubated in organ culture. Placental tissue maintains a constant pool of hPL. The synthesis of hPL may be the driving force for its secretion. The de novo synthesis and secretion rates of hPL were also investigated. The higher specific radioactivities of the secreted hPL than those found in the tissue may suggest that newly synthesized hPL is preferentially released. The intracellular distribution of hPL was also compared.

Original language	English
Pages (from-to)	189-199
Number of pages	11
Journal	Molecular and Cellular Endocrinology
Volume	26
Issue number	1-2
DOIs	https://doi.org/10.1016/0303-7207(82)90016-8
State	Published - Apr 1982

Keywords

human placental lactogen
organ culture
placenta

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10.1016/0303-7207(82)90016-8

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abstract = "We studied the in vitro synthesis and secretion of hPL by human term placental tissue incubated in organ culture. Placental tissue maintains a constant pool of hPL. The synthesis of hPL may be the driving force for its secretion. The de novo synthesis and secretion rates of hPL were also investigated. The higher specific radioactivities of the secreted hPL than those found in the tissue may suggest that newly synthesized hPL is preferentially released. The intracellular distribution of hPL was also compared.",

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AU - Groot, Nathan de

AU - Ilan, Judith

AU - Folman, Rachel

AU - Hochberg, Abraham A.

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The synthesis and secretion of human placental lactogen (hPL) in cultured term placenta

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Keywords

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