The synthesis and secretion of human placental lactogen (hPL) in cultured term placenta

Daniel Weinstein*, Hanan Galski, Joseph G. Schenker, Haya Lorberboum, Nathan de Groot, Judith Ilan, Rachel Folman, Abraham A. Hochberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We studied the in vitro synthesis and secretion of hPL by human term placental tissue incubated in organ culture. Placental tissue maintains a constant pool of hPL. The synthesis of hPL may be the driving force for its secretion. The de novo synthesis and secretion rates of hPL were also investigated. The higher specific radioactivities of the secreted hPL than those found in the tissue may suggest that newly synthesized hPL is preferentially released. The intracellular distribution of hPL was also compared.

Original languageAmerican English
Pages (from-to)189-199
Number of pages11
JournalMolecular and Cellular Endocrinology
Volume26
Issue number1-2
DOIs
StatePublished - Apr 1982

Keywords

  • human placental lactogen
  • organ culture
  • placenta

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