TY - JOUR
T1 - The taste of the pandemic—contemporary review on the current state of research on gustation in coronavirus disease 2019 (COVID-19)
AU - Hintschich, Constantin A.
AU - Niv, Masha Y.
AU - Hummel, Thomas
N1 - Publisher Copyright:
© 2021 The Authors. International Forum of Allergy & Rhinology published by Wiley Periodicals LLC on behalf of American Academy of Otolaryngic Allergy and American Rhinologic Society
PY - 2022/2
Y1 - 2022/2
N2 - Subjectively perceived impairment of taste is a common and distinct symptom of coronavirus disease 2019 (COVID-19). Large meta-analyses identified this symptom in approximately 50% of cases. However, this high prevalence is not supported by blinded and validated psychophysical gustatory testing, which showed a much lower prevalence in up to 26% of patients. This discrepancy may be due to misinterpretation of impaired retronasal olfaction as gustatory dysfunction. In addition, we hypothesized that COVID-19–associated hyposmia is involved in the decrease of gustatory function, as found for hyposmia of different origin. This indirect mechanism would be based on the central-nervous mutual amplification between the chemical senses, which fails in COVID-19–associated olfactory loss. However, further research is necessary on how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) may directly impair the gustatory pathway as well as its subjective perception.
AB - Subjectively perceived impairment of taste is a common and distinct symptom of coronavirus disease 2019 (COVID-19). Large meta-analyses identified this symptom in approximately 50% of cases. However, this high prevalence is not supported by blinded and validated psychophysical gustatory testing, which showed a much lower prevalence in up to 26% of patients. This discrepancy may be due to misinterpretation of impaired retronasal olfaction as gustatory dysfunction. In addition, we hypothesized that COVID-19–associated hyposmia is involved in the decrease of gustatory function, as found for hyposmia of different origin. This indirect mechanism would be based on the central-nervous mutual amplification between the chemical senses, which fails in COVID-19–associated olfactory loss. However, further research is necessary on how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) may directly impair the gustatory pathway as well as its subjective perception.
UR - http://www.scopus.com/inward/record.url?scp=85118178928&partnerID=8YFLogxK
U2 - 10.1002/alr.22902
DO - 10.1002/alr.22902
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C2 - 34704387
AN - SCOPUS:85118178928
SN - 2042-6976
VL - 12
SP - 210
EP - 216
JO - International Forum of Allergy and Rhinology
JF - International Forum of Allergy and Rhinology
IS - 2
ER -
