The tetrameric structure of a glutamate receptor channel

Christian Rosenmund, Yael Stern-Bach, Charles F. Stevens*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

661 Scopus citations

Abstract

The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

Original languageAmerican English
Pages (from-to)1596-1599
Number of pages4
JournalScience
Volume280
Issue number5369
DOIs
StatePublished - 5 Jun 1998

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