The tetrameric structure of a glutamate receptor channel

Christian Rosenmund; Yael Stern-Bach; Charles F. Stevens

doi:10.1126/science.280.5369.1596

The tetrameric structure of a glutamate receptor channel

Christian Rosenmund, Yael Stern-Bach, Charles F. Stevens^*

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

662 Scopus citations

Abstract

The subunit stoichiometry of several ligand-gated ion channel receptors is still unknown. A counting method was developed to determine the number of subunits in one family of brain glutamate receptors. Successful application of this method in an HEK cell line provides evidence that ionotropic glutamate receptors share a tetrameric structure with the voltage-gated potassium channels. The average conductance of these channels depends on how many subunits are occupied by an agonist.

Original language	English
Pages (from-to)	1596-1599
Number of pages	4
Journal	Science
Volume	280
Issue number	5369
DOIs	https://doi.org/10.1126/science.280.5369.1596
State	Published - 5 Jun 1998

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10.1126/science.280.5369.1596

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The tetrameric structure of a glutamate receptor channel

Abstract

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