The toxicity of macrocyclic trichothecenes administered directly into the rat brain

Felix Bergmann*, Boris Yagen, Bruce B. Jarvis

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The tested macrocyclic trichothecenes are produced by Myrothecium fungi and by the plant Baccharis megapotamica. The toxicity of five macrocyclic trichothecenes has been measured by intracerebral and subcutaneous injection into rats. It is assumed that the toxic effects are based on inhibition of protein synthesis. Intoxication of rats by these compounds finds expression in slowly progressing respiratory depression and paralysis of skeletal muscles. The macrocyclics are derived from verrucarol, which lacks ring D and exhibits only low toxicity. The high toxicity of the macrocyclics, established by intracerebral and subcutaneous applications, may thus be attributed to the presence of the large ring D.

Original languageEnglish
Pages (from-to)1291-1294
Number of pages4
JournalToxicon
Volume30
Issue number10
DOIs
StatePublished - Oct 1992

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