The toxicity of T-2 toxin and diacetoxyscirpenol in combination for broiler chickens

F. J. Hoerr*, W. W. Carlton, B. Yagen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

T-2 toxin and diacetoxyscirpenol, two naturally occurring trichothecene mycotoxins, were dissolved in dimethylsulphoxide:saline (1:9, v/v) and administered separately and in combinations to 7-day-old male broiler chickens. The 72-hr single oral dose LD50 for T-2 toxin was 4·0 mg/kg body weight and for diacetoxyscirpenol, it was 5·0 mg/kg. T-2 toxin administered as 14 daily oral doses had an LD50 of 2·90 mg/kg, and diacetoxyscirpenol had an LD50 of 4·15 mg/kg. Combinations of the toxins caused additive lethal effects in both the single- and multiple-dose tests.

Original languageEnglish
Pages (from-to)185-188
Number of pages4
JournalFood and Cosmetics Toxicology
Volume19
Issue numberC
DOIs
StatePublished - 1981

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