TY - JOUR
T1 - The toxicity of T-2 toxin and diacetoxyscirpenol in combination for broiler chickens
AU - Hoerr, F. J.
AU - Carlton, W. W.
AU - Yagen, B.
PY - 1981
Y1 - 1981
N2 - T-2 toxin and diacetoxyscirpenol, two naturally occurring trichothecene mycotoxins, were dissolved in dimethylsulphoxide:saline (1:9, v/v) and administered separately and in combinations to 7-day-old male broiler chickens. The 72-hr single oral dose LD50 for T-2 toxin was 4·0 mg/kg body weight and for diacetoxyscirpenol, it was 5·0 mg/kg. T-2 toxin administered as 14 daily oral doses had an LD50 of 2·90 mg/kg, and diacetoxyscirpenol had an LD50 of 4·15 mg/kg. Combinations of the toxins caused additive lethal effects in both the single- and multiple-dose tests.
AB - T-2 toxin and diacetoxyscirpenol, two naturally occurring trichothecene mycotoxins, were dissolved in dimethylsulphoxide:saline (1:9, v/v) and administered separately and in combinations to 7-day-old male broiler chickens. The 72-hr single oral dose LD50 for T-2 toxin was 4·0 mg/kg body weight and for diacetoxyscirpenol, it was 5·0 mg/kg. T-2 toxin administered as 14 daily oral doses had an LD50 of 2·90 mg/kg, and diacetoxyscirpenol had an LD50 of 4·15 mg/kg. Combinations of the toxins caused additive lethal effects in both the single- and multiple-dose tests.
UR - http://www.scopus.com/inward/record.url?scp=0019828048&partnerID=8YFLogxK
U2 - 10.1016/0015-6264(81)90356-4
DO - 10.1016/0015-6264(81)90356-4
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C2 - 7286869
AN - SCOPUS:0019828048
SN - 0015-6264
VL - 19
SP - 185
EP - 188
JO - Food and Cosmetics Toxicology
JF - Food and Cosmetics Toxicology
IS - C
ER -