The Trypanosoma brucei telomerase RNA (TER) homologue binds core proteins of the C/D snoRNA family

Sachin Kumar Gupta, Liat Kolet, Tirza Doniger, Viplov Kumar Biswas, Ron Unger, Yehuda Tzfati, Shulamit Michaeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Trypanosome protozoan parasites are the causative agents of devastating diseases. Trypanosome telomeres grow in an uncontrolled manner and the variant surface glycoprotein (VSG) genes are located in subtelomeric domains. The gene encoding telomerase reverse transcriptase (TERT) was identified and in this study, we describe the Trypanosoma brucei telomerase RNA (TER). TER RNA is bound by the core proteins of the C/D small nucleolar RNA (snoRNA) family and associates with the methyltransferase-associated protein (MTAP), whose homologue binds to mammalian TER. Silencing of TbTER resulted in telomere shortening. This is the first report of a TER that binds the C/D snoRNA core proteins.

Original languageAmerican English
Pages (from-to)1399-1404
Number of pages6
JournalFEBS Letters
Volume587
Issue number9
DOIs
StatePublished - 2 May 2013

Bibliographical note

Funding Information:
This work was supported by a grant from the Israel–US Binational Science Foundation (BSF) to S.M. Who holds the David and Inez Myers Chair in RNA silencing of diseases and another BSF grant to Y.T. We thank Dr. Itai Tkacz for the help in RNA-seq.

Keywords

  • C/D snoRNA
  • TER RNA
  • Telomerase
  • Trans-splicing of non-coding RNAs
  • Trypanosoma brucei

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