The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is frequently altered in cancer. WWOX binds several proteins and thus is postulated to be involved in a variety of cellular processes. Interestingly, Wwox-knockout mice develop normally in utero but succumb to hypoglycemia and other metabolic defects early in life resulting in their death by 3–4 weeks of age. Cumulative evidence has linked WWOX with cellular metabolism including steroid metabolism, high-density lipoprotein cholesterol (HDL-C) metabolism, bone metabolism and, more recently, glucose metabolism. In this review, we discuss these evolving functions for WWOX and how its deletion affects cellular metabolism and neoplastic progression.
Bibliographical noteFunding Information:
The Aqeilan lab is funded, in part, by the Association for International Cancer Research (AICR).
© 2014 by the Society for Experimental Biology and Medicine
- WW domain-containing oxidoreductase
- aerobic glycolysis
- hypoxia-inducible transcription factor 1
- tumor suppressor