The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism

Muhannad Abu-Remaileh, Rami I. Aqeilan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The WW domain-containing oxidoreductase (WWOX) encodes a tumor suppressor that is frequently altered in cancer. WWOX binds several proteins and thus is postulated to be involved in a variety of cellular processes. Interestingly, Wwox-knockout mice develop normally in utero but succumb to hypoglycemia and other metabolic defects early in life resulting in their death by 3–4 weeks of age. Cumulative evidence has linked WWOX with cellular metabolism including steroid metabolism, high-density lipoprotein cholesterol (HDL-C) metabolism, bone metabolism and, more recently, glucose metabolism. In this review, we discuss these evolving functions for WWOX and how its deletion affects cellular metabolism and neoplastic progression.

Original languageAmerican English
Pages (from-to)345-350
Number of pages6
JournalExperimental Biology and Medicine
Issue number3
StatePublished - 25 Mar 2015
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2014 by the Society for Experimental Biology and Medicine


  • WW domain-containing oxidoreductase
  • aerobic glycolysis
  • hypoxia-inducible transcription factor 1
  • metabolism
  • tumor suppressor


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