The two facets of gp130 signalling in liver tumorigenesis

Dirk Schmidt-Arras; Eithan Galun; Stefan Rose-John

doi:10.1007/s00281-021-00861-0

The two facets of gp130 signalling in liver tumorigenesis

Dirk Schmidt-Arras^*
, Eithan Galun^*
, Stefan Rose-John^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the receptor subunit gp130 and the downstream signalling molecule STAT3. We here summarize current knowledge on how gp130 signalling and STAT3 in tumour cells and cells of the tumour micro-environment drives hepatic tumorigenesis. We furthermore discuss very recent findings describing also anti-tumorigenic roles of gp130/STAT3 and important considerations for therapeutic interventions.

Original language	English
Pages (from-to)	609-624
Number of pages	16
Journal	Seminars in Immunopathology
Volume	43
Issue number	4
DOIs	https://doi.org/10.1007/s00281-021-00861-0
State	Published - Aug 2021

Bibliographical note

Publisher Copyright:
© 2021, The Author(s).

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anti-tumour immunity
Cholangiocarcinoma (CCA)
Hepatocellular carcinoma (HCC)
IL-6
Inflammation
STAT3
Tumour micro-environment
gp130

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10.1007/s00281-021-00861-0

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abstract = "The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the receptor subunit gp130 and the downstream signalling molecule STAT3. We here summarize current knowledge on how gp130 signalling and STAT3 in tumour cells and cells of the tumour micro-environment drives hepatic tumorigenesis. We furthermore discuss very recent findings describing also anti-tumorigenic roles of gp130/STAT3 and important considerations for therapeutic interventions.",

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AB - The liver is a vital organ with multiple functions and a large regenerative capacity. Tumours of the liver are the second most frequently cause of cancer-related death and develop in chronically inflamed livers. IL-6-type cytokines are mediators of inflammation and almost all members signal via the receptor subunit gp130 and the downstream signalling molecule STAT3. We here summarize current knowledge on how gp130 signalling and STAT3 in tumour cells and cells of the tumour micro-environment drives hepatic tumorigenesis. We furthermore discuss very recent findings describing also anti-tumorigenic roles of gp130/STAT3 and important considerations for therapeutic interventions.

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KW - Hepatocellular carcinoma (HCC)

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KW - Inflammation

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KW - gp130

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The two facets of gp130 signalling in liver tumorigenesis

Abstract

Bibliographical note

UN SDGs

Keywords

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