The Unique Properties of Uterine NK Cells

Irit Manaster, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

159 Scopus citations

Abstract

Citation Manaster I, Mandelboim O. The unique properties of uterine NK cells. Am J Reprod Immunol 2009. Natural killer (NK) cells are lymphocytes of the innate immunity system that are able to kill various hazardous pathogens and tumors. However, it is now widely accepted that NK cells also possess non-destructive functions, as has been demonstrated for uterine NK cells. Here, we review the unique properties of the NK cells in the uterine mucosa, prior to and during pregnancy. We discuss the phenotype and function of mouse and human endometrial and decidual NK cells and suggest that the major function of decidual NK cells is to assist in fetal development. We further discuss the origin of decidual NK cells and suggest several possibilities that might explain their accumulation in the decidua during pregnancy.

Original languageAmerican English
Pages (from-to)434-444
Number of pages11
JournalAmerican Journal of Reproductive Immunology
Volume63
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • Decidual NK cells
  • Endometrial NK cells
  • Pregnancy

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