The use of microRNA by human viruses: Lessons from NK cells and HCMV infection

Tal Goldberger, Ofer Mandelboim*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


Depending on ethnicity and on social conditions, between 40 and 90 % of the population is infected with human cytomegalovirus (HCMV). In immunocompetent patients, the virus may cause an acute disease and then revert to a state of latency, which enables its coexistence with the human host. However, in cases of immunosuppression or in neonatal infections, HCMV can cause serious long-lasting illnesses. HCMV has developed multiple mechanisms in order to escape its elimination by the immune system, specifically by two killer cell types of the adaptive and the innate immune systems; cytotoxic T lymphocytes (CTL) and natural killer (NK) cells, respectively. Another fascinating aspect of HCMV is that like other highly developed herpesviruses, it expresses its own unique set of microRNAs. Here, we initially describe how the activity of NK cells is regulated under normal conditions and during infection. Then, we discuss what is currently known about HCMV microRNA-mediated interactions, with special emphasis on immune modulation and NK cell evasion. We further illustrate the significant modulation of cellular microRNAs during HCMV infection. Although, the full target spectrum of HCMV microRNAs is far from being completely elucidated, it can already be concluded that HCMV uses its “multitasking” microRNAs to globally affect its own life cycle, as well as important cellular and immune-related pathways.

Original languageAmerican English
Pages (from-to)659-674
Number of pages16
JournalSeminars in Immunopathology
Issue number6
StatePublished - Nov 2014

Bibliographical note

Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.


  • Cytomegalovirus
  • HCMV
  • Immune evasion
  • Immune modulation
  • MicroRNA
  • NK cells


Dive into the research topics of 'The use of microRNA by human viruses: Lessons from NK cells and HCMV infection'. Together they form a unique fingerprint.

Cite this