The use of phospholipid liposomes for lithium administration. Polydipsic effect and tissue distribution of lithium

Administration of lithium entrapped in phospholipid liposomes increased the lithium‐induced polydipsia, but did not accelerate the onset of this effect. It also resulted in a larger accumulation of lithium in the liver, kidney and spleen, but not in the brain. The time course of polydipsia suggests that it depends on the intracellular lithium concentration. However, the rate of development of this effect depends on some additional factor. 1979 Royal Pharmaceutical Society of Great Britain