The vascular niche in adult neurogenesis

Tamar Licht; Eli Keshet

doi:10.1016/j.mod.2015.06.001

The vascular niche in adult neurogenesis

Tamar Licht, Eli Keshet^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

79 Scopus citations

Abstract

Blood vessels (BVs) not only serve as conduits for oxygen and nutrients but may also fulfill perfusion-independent functions. A growing body of data suggests that blood vessels are an integral component of stem cell niches, including stem cell niches in the adult brain. This review summarizes in vivo studies supporting the contention that blood vessels may indeed control function of neuronal stem cells (NSCs) residing in the two major neurogenic niches of the adult brain, namely the sub-ventricular zone and the hippocampus. The review discusses different modes of BV-NSC communication and possible mechanisms by which BV may modulate NSC behavior and responses to external stimuli.

Original language	English
Pages (from-to)	56-62
Number of pages	7
Journal	Mechanisms of Development
Volume	138
DOIs	https://doi.org/10.1016/j.mod.2015.06.001
State	Published - 1 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 Elsevier B.V.

Keywords

Adult neurogenesis
Angiogenesis
Neural stem cells
Neurovascular unit

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10.1016/j.mod.2015.06.001

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abstract = "Blood vessels (BVs) not only serve as conduits for oxygen and nutrients but may also fulfill perfusion-independent functions. A growing body of data suggests that blood vessels are an integral component of stem cell niches, including stem cell niches in the adult brain. This review summarizes in vivo studies supporting the contention that blood vessels may indeed control function of neuronal stem cells (NSCs) residing in the two major neurogenic niches of the adult brain, namely the sub-ventricular zone and the hippocampus. The review discusses different modes of BV-NSC communication and possible mechanisms by which BV may modulate NSC behavior and responses to external stimuli.",

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KW - Adult neurogenesis

KW - Angiogenesis

KW - Neural stem cells

KW - Neurovascular unit

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The vascular niche in adult neurogenesis

Abstract

Bibliographical note

Keywords

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