The yeast HOG pathway is activated in response to increased osmolarity and affects many cellular activities. As cells lacking Hog1 are osmo-sensitive it is believed that Hog1 is essential for survival under osmostress. We show, however, that hog1Δ cells survive and even proliferate to some degree under high osmostress for many hours. If forced to enter G1/G0 prior the exposure to osmostress, hog1Δ cells survive for at least 6 days. We suggest that the primary role of Hog1 is not to preserve viability upon exposure to stress. We discuss the possibility that Hog1 is needed for proliferation under osmostress.
Bibliographical noteFunding Information:
We thank Chen Ifrach for assisting with the genetic screen, Dan Lehmann for assisting with FACS analysis, Ariel stanhill for reviewing the manuscript and M. Gustin and G.R. Fink for strains and genomic library. The study was supported by a grant from the Israel Science Foundation, #656/06.
- Cell cycle