The yeast MAPK Hog1 is not essential for immediate survival under osmostress

Inbal Maayan, David Engelberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


The yeast HOG pathway is activated in response to increased osmolarity and affects many cellular activities. As cells lacking Hog1 are osmo-sensitive it is believed that Hog1 is essential for survival under osmostress. We show, however, that hog1Δ cells survive and even proliferate to some degree under high osmostress for many hours. If forced to enter G1/G0 prior the exposure to osmostress, hog1Δ cells survive for at least 6 days. We suggest that the primary role of Hog1 is not to preserve viability upon exposure to stress. We discuss the possibility that Hog1 is needed for proliferation under osmostress.

Original languageAmerican English
Pages (from-to)2015-2020
Number of pages6
JournalFEBS Letters
Issue number12
StatePublished - 18 Jun 2009

Bibliographical note

Funding Information:
We thank Chen Ifrach for assisting with the genetic screen, Dan Lehmann for assisting with FACS analysis, Ariel stanhill for reviewing the manuscript and M. Gustin and G.R. Fink for strains and genomic library. The study was supported by a grant from the Israel Science Foundation, #656/06.


  • Cell cycle
  • Hog1
  • Osmostress
  • Rck2
  • Yeast


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