Theoretical studies of catalysis by carboxypeptidase A: Could gas-phase calculations support a mechanism?

Keyphrases

• Gas Phase 100%
• Carboxypeptidase 100%
• Phase Calculation 100%
• Zinc 50%
• Dipeptide 50%
• Nucleophilic 50%
• Peptide Cleavage 50%
• General Base 50%
• General Acid 50%
• Active Sites 25%
• Chemical Entities 25%
• Peptide Bond 25%
• Water Molecule 25%
• Reaction Pathway 25%
• Proton Transfer 25%
• Alternative Pathway 25%
• Large Animal Model 25%
• D-orbital 25%
• Bond Formation 25%
• Proteinase 25%
• Non-catalytic Reaction 25%
• Multiple H-bond 25%
• Non-catalytic 25%
• Catalytic Route 25%
• Reduced Representation 25%
• Quantum Mechanical Computation 25%

Chemistry

• Base 100%
• Dipeptide 100%
• Catalytic Reaction 50%
• Proton Transfer 50%
• MNDO Calculation 50%
• formation 50%
• Hydrogen Bond 50%

Biochemistry, Genetics and Molecular Biology

• Carboxypeptidase A 100%
• Nucleophilicity 50%
• Peptide Cleavage 50%
• Dipeptide 50%
• Enzyme 25%
• Active Site 25%
• Proton Transport 25%
• Zinc 25%
• Catalysis 25%
• Peptide Bond 25%
• Protease 25%