TY - JOUR
T1 - Theranostic barcoded nanoparticles for personalized cancer medicine
AU - Yaari, Zvi
AU - Da Silva, Dana
AU - Zinger, Assaf
AU - Goldman, Evgeniya
AU - Kajal, Ashima
AU - Tshuva, Rafi
AU - Barak, Efrat
AU - Dahan, Nitsan
AU - Hershkovitz, Dov
AU - Goldfeder, Mor
AU - Roitman, Janna Shainsky
AU - Schroeder, Avi
N1 - Publisher Copyright:
© 2016 The Author(s).
PY - 2016/11/10
Y1 - 2016/11/10
N2 - Personalized medicine promises to revolutionize cancer therapy by matching the most effective treatment to the individual patient. Using a nanoparticle-based system, we predict the therapeutic potency of anticancer medicines in a personalized manner. We carry out the diagnostic stage through a multidrug screen performed inside the tumour, extracting drug activity information with single cell sensitivity. By using 100 nm liposomes, loaded with various cancer drugs and corresponding synthetic DNA barcodes, we find a correlation between the cell viability and the drug it was exposed to, according to the matching barcodes. Based on this screen, we devise a treatment protocol for mice bearing triple-negative breast-cancer tumours, and its results confirm the diagnostic prediction. We show that the use of nanotechnology in cancer care is effective for generating personalized treatment protocols.
AB - Personalized medicine promises to revolutionize cancer therapy by matching the most effective treatment to the individual patient. Using a nanoparticle-based system, we predict the therapeutic potency of anticancer medicines in a personalized manner. We carry out the diagnostic stage through a multidrug screen performed inside the tumour, extracting drug activity information with single cell sensitivity. By using 100 nm liposomes, loaded with various cancer drugs and corresponding synthetic DNA barcodes, we find a correlation between the cell viability and the drug it was exposed to, according to the matching barcodes. Based on this screen, we devise a treatment protocol for mice bearing triple-negative breast-cancer tumours, and its results confirm the diagnostic prediction. We show that the use of nanotechnology in cancer care is effective for generating personalized treatment protocols.
UR - http://www.scopus.com/inward/record.url?scp=84994831683&partnerID=8YFLogxK
U2 - 10.1038/ncomms13325
DO - 10.1038/ncomms13325
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C2 - 27830705
AN - SCOPUS:84994831683
SN - 2041-1723
VL - 7
JO - Nature Communications
JF - Nature Communications
M1 - 13325
ER -
