TY - JOUR
T1 - Therapeutic effect of doxycycline in experimental subclinical canine monocytic ehrlichiosis
T2 - Evaluation of a 6-week course
AU - Harrus, S.
AU - Waner, T.
AU - Aizenberg, I.
AU - Bark, H.
PY - 1998
Y1 - 1998
N2 - The efficacy of doxycycline treatment (10 mg/kg of body weight every 24 h for 42 days) in eliminating Ehrlichia canis from four subclinically infected dogs was evaluated. One dog remained PCR positive, suggesting that 6 weeks of doxycycline treatment may not be sufficient to clear E. canis parasites from all subclinically infected dogs. Serology (indirect immunofluorescent antibody assay) was shown to be unreliable in assessing recovery from the carrier state, as anti-E. canis antibodies persisted after elimination of the parasite. Our findings suggest that an increase in the platelet count may be an important indicator for dogs that recover from subclinical ehrlichiosis.
AB - The efficacy of doxycycline treatment (10 mg/kg of body weight every 24 h for 42 days) in eliminating Ehrlichia canis from four subclinically infected dogs was evaluated. One dog remained PCR positive, suggesting that 6 weeks of doxycycline treatment may not be sufficient to clear E. canis parasites from all subclinically infected dogs. Serology (indirect immunofluorescent antibody assay) was shown to be unreliable in assessing recovery from the carrier state, as anti-E. canis antibodies persisted after elimination of the parasite. Our findings suggest that an increase in the platelet count may be an important indicator for dogs that recover from subclinical ehrlichiosis.
UR - http://www.scopus.com/inward/record.url?scp=0031809036&partnerID=8YFLogxK
U2 - 10.1128/jcm.36.7.2140-2142.1998
DO - 10.1128/jcm.36.7.2140-2142.1998
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C2 - 9650986
AN - SCOPUS:0031809036
SN - 0095-1137
VL - 36
SP - 2140
EP - 2142
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
IS - 7
ER -