Thrombin-induced degranulation of cultured bone marrow-derived mast cells

E. Razin, G. Marx

Research output: Contribution to journalArticlepeer-review

93 Scopus citations

Abstract

This study was undertaken to determine if a plasma protease such as thrombin, a highly specific procoagulant enzyme that has numerous effects on platelets, endothelial cells, and smooth muscle cells, could mediate mast cell activation processes. Our results indicate that at near physiologic levels, thrombin can rapidly trigger mast cell degranulation without activating the 5-lipoxygenase system.

Original languageEnglish
Pages (from-to)3282-3285
Number of pages4
JournalJournal of Immunology
Volume133
Issue number6
StatePublished - 1984

Fingerprint

Dive into the research topics of 'Thrombin-induced degranulation of cultured bone marrow-derived mast cells'. Together they form a unique fingerprint.

Cite this