Thromboembolism in dogs with protein-losing enteropathy with non-neoplastic chronic small intestinal disease

Ana M.L. Jacinto*, Alison E. Ridyard, Itamar Aroch, Penny J. Watson, Linda R. Morrison, Marge L. Chandler, Sharon Kuzi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Dogs with protein-losing enteropathy (PLE) are suggested to be at increased risk of developing thromboembolic events. However, with some exceptions, there are very few reports of thromboembolism in such dogs. This multicentre retrospective observational study describes a case series of thromboembolism (TE) in eight dogs with PLE secondary to non-neoplastic, chronic small intestinal disease. Seven dogs had poorly controlled PLE when the thromboembolic event occurred. Pulmonary thromboembolism (PTE) occurred in six dogs, while one dog developed splenic vein thrombosis and another had concurrent splenic vein and aortic TE. Six dogs died, all with PTE. Antithrombin activity was decreased in one of two dogs in which it was measured. Serum cobalamin and folate concentrations were measured in three dogs and cobalamin was subnormal in all three. Serum magnesium, measured in two dogs, was low in both. Dogs with uncontrolled chronic small intestinal disease and PLE are at risk for developing serious life-threatening TE, mostly PTE.

Original languageAmerican English
Pages (from-to)185-192
Number of pages8
JournalJournal of the American Animal Hospital Association
Issue number3
StatePublished - 2017

Bibliographical note

Publisher Copyright:
© 2017 by American Animal Hospital Association.


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