Thrombolytic therapy reduces red blood cell aggregation in plasma without affecting intrinsic aggregability

R. Ben-Ami*, G. Sheinman, S. Yedgar, A. Eldor, A. Roth, A. S. Berliner, G. Barshtein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Red blood cell (RBC) aggregation may contribute to occlusion of the coronary microcirculation during myocardial infarction. We studied the effect of thrombolytic therapy on RBC aggregation in patients with acute myocardial infarction (AMI). Compared with patients with myocardial infarction who did not receive thrombolytic therapy, those treated with systemic thrombolysis exhibited significantly reduced RBC aggregation, reduced plasma fibrinogen levels and increased plasma D-dimer levels. Using measurement of RBC aggregation in a standardized dextran-500 solution, reduction in RBC aggregation after thrombolysis was shown to be plasma dependent. Thrombolytic therapy had no direct effect on intrinsic RBC aggregability in patients with AMI. We conclude that thrombolytic therapy has rheologic consequences that may contribute to its overall efficacy. Inhibition of RBC aggregation by thrombolytic therapy may result from the degradation of fibrinogen, a key factor in the formation of RBC aggregates, and from the generation of fibrinogen degradation products capable of disaggregating RBCs.

Original languageAmerican English
Pages (from-to)487-492
Number of pages6
JournalThrombosis Research
Volume105
Issue number6
DOIs
StatePublished - 15 Mar 2002

Bibliographical note

Funding Information:
This work is dedicated to the memory of Professor Amiram Eldor. The study was supported by a grant to S. Yedgar from the Israel Ministry of Science (1460-1-99). We are indebted to O. Fredman and S. Levi for their technical assistance.

Keywords

  • Erythrocyte aggregation
  • Fibrinogen
  • Myocardial infarction
  • Plasminogen activators

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