Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia

Shlomit Barzilai-Birenboim*, Nira Arad-Cohen, Ronit Nirel, Galia Avrahami, Dan Harlev, Gil Gilad, Ronit Elhasid, Shai Izraeli, Naomi Litichever, Sarah Elitzur

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at-risk patients with ALL.

Original languageAmerican English
Pages (from-to)994-998
Number of pages5
JournalBritish Journal of Haematology
Volume184
Issue number6
DOIs
StatePublished - Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 British Society for Haematology and John Wiley & Sons Ltd

Keywords

  • factor V Leiden
  • paediatric acute lymphoblastic leukaemia
  • prophylactic low molecular weight heparin
  • thrombophilia
  • venous thromboembolism

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