Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia

Shlomit Barzilai-Birenboim; Nira Arad-Cohen; Ronit Nirel; Galia Avrahami; Dan Harlev; Gil Gilad; Ronit Elhasid; Shai Izraeli; Naomi Litichever; Sarah Elitzur

doi:10.1111/bjh.15752

Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia

Shlomit Barzilai-Birenboim^*, Nira Arad-Cohen, Ronit Nirel, Galia Avrahami, Dan Harlev, Gil Gilad, Ronit Elhasid, Shai Izraeli, Naomi Litichever, Sarah Elitzur

^*Corresponding author for this work

Department of Statistics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at-risk patients with ALL.

Original language	English
Pages (from-to)	994-998
Number of pages	5
Journal	British Journal of Haematology
Volume	184
Issue number	6
DOIs	https://doi.org/10.1111/bjh.15752
State	Published - Mar 2019

Bibliographical note

Publisher Copyright:
© 2019 British Society for Haematology and John Wiley & Sons Ltd

Keywords

factor V Leiden
paediatric acute lymphoblastic leukaemia
prophylactic low molecular weight heparin
thrombophilia
venous thromboembolism

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/bjh.15752

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title = "Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia",

abstract = "This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at-risk patients with ALL.",

keywords = "factor V Leiden, paediatric acute lymphoblastic leukaemia, prophylactic low molecular weight heparin, thrombophilia, venous thromboembolism",

author = "Shlomit Barzilai-Birenboim and Nira Arad-Cohen and Ronit Nirel and Galia Avrahami and Dan Harlev and Gil Gilad and Ronit Elhasid and Shai Izraeli and Naomi Litichever and Sarah Elitzur",

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year = "2019",

month = mar,

doi = "10.1111/bjh.15752",

language = "אנגלית",

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AU - Barzilai-Birenboim, Shlomit

AU - Arad-Cohen, Nira

AU - Nirel, Ronit

AU - Avrahami, Galia

AU - Harlev, Dan

AU - Gilad, Gil

AU - Elhasid, Ronit

AU - Izraeli, Shai

AU - Litichever, Naomi

AU - Elitzur, Sarah

PY - 2019/3

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N2 - This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at-risk patients with ALL.

AB - This study investigated the prevalence of inherited thrombophilia, risk of venous thromboembolism (VTE) and benefit of low molecular weight heparin prophylaxis in 476 Israeli children with acute lymphoblastic leukaemia (ALL) treated between 2004 and 2016. Thrombophilia was found in 15·5%. Arab children had a higher prevalence of F5 R506Q (factor V Leiden) than Jewish children (19·4% vs. 2·9%, P < 0·01). Patients with thrombophilia had higher VTE rates VTE (26·5% vs. 5·6%, P < 0·001). None of the thrombophilic children given prophylaxis had severe VTE. Routine evaluation for inherited thrombophilia followed by thromboprophylaxis when findings are positive may benefit at-risk patients with ALL.

KW - factor V Leiden

KW - paediatric acute lymphoblastic leukaemia

KW - prophylactic low molecular weight heparin

KW - thrombophilia

KW - venous thromboembolism

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VL - 184

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EP - 998

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 6

ER -

Thrombophilia screening and thromboprophylaxis may benefit specific ethnic subgroups with paediatric acute lymphoblastic leukaemia

Abstract

Bibliographical note

Keywords

UN SDGs

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