Time domain dielectric spectroscopy study of human cells II. Normal and malignant white blood cells

Yulia Polevaya, Irina Ermolina, Michael Schlesinger, Ben Zion Ginzburg, Yuri Feldman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

199 Scopus citations

Abstract

The dielectric properties of human lymphocyte suspensions were studied by time domain dielectric spectroscopy (TDDS). Nine populations of malignant and normal lymphocytes were investigated. Analysis of the dielectric parameters of cell structural parts were performed in the framework of Maxwell-Wagner mixture formula and the double-shell model of cell. The specific capacitance of the cell membranes was estimated by the Hanai-Asami-Koisumi formula. It was shown that the dielectric permittivity, capacitance and conductivity values of cell membranes are higher for normal lymphocytes than for the malignant ones. The difference of the same parameters for normal B- and T-cells is also discussed. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)257-271
Number of pages15
JournalBiochimica et Biophysica Acta - Biomembranes
Volume1419
Issue number2
DOIs
StatePublished - 15 Jul 1999

Keywords

  • Blood cancer
  • Cell membrane
  • Dielectric property
  • Electrode polarization
  • Human lymphocyte suspension
  • Nuclear envelope

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