Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites

Vera Mitesser, Karina Simantov, Ron Dzikowski

Research output: Contribution to journalReview articlepeer-review

Abstract

Long noncoding RNAs (lncRNA) are emerging as important regulators of gene expression in eukaryotes. In recent years, a large repertoire of lncRNA were discovered in Apicomplexan parasites and were implicated in several mechanisms of gene expression, including marking genes for activation, contributing to the formation of subnuclear compartments and organization, regulating the deposition of epigenetic modifications, influencing chromatin and chromosomal structure and manipulating host gene expression. Here, we aim to update recent knowledge on the role of lncRNAs as regulators in Apicomplexan parasites and highlight the possible molecular mechanisms by which they function. We hope that some of the hypotheses raised here will contribute to further investigation and lead to new mechanistic insight and better understanding of the role of lncRNA in parasite's biology.

Original languageAmerican English
Article number102484
JournalCurrent Opinion in Microbiology
Volume79
DOIs
StatePublished - Jun 2024

Bibliographical note

Publisher Copyright:
© 2024 Elsevier Ltd

Fingerprint

Dive into the research topics of 'Time to switch gears: how long noncoding RNAs function as epigenetic regulators in Apicomplexan parasites'. Together they form a unique fingerprint.

Cite this