TY - JOUR
T1 - Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3)
AU - DeVinney, R.
AU - Nisan, I.
AU - Ruschkowski, S.
AU - Rosenshine, I.
AU - Finlay, B. B.
PY - 2001
Y1 - 2001
N2 - Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.
AB - Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.
UR - http://www.scopus.com/inward/record.url?scp=0035172766&partnerID=8YFLogxK
U2 - 10.1128/IAI.69.1.559-563.2001
DO - 10.1128/IAI.69.1.559-563.2001
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C2 - 11119553
AN - SCOPUS:0035172766
SN - 0019-9567
VL - 69
SP - 559
EP - 563
JO - Infection and Immunity
JF - Infection and Immunity
IS - 1
ER -