Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3)

R. DeVinney; I. Nisan; S. Ruschkowski; I. Rosenshine; B. B. Finlay

doi:10.1128/IAI.69.1.559-563.2001

Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3)

R. DeVinney, I. Nisan, S. Ruschkowski, I. Rosenshine, B. B. Finlay^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.

Original language	American English
Pages (from-to)	559-563
Number of pages	5
Journal	Infection and Immunity
Volume	69
Issue number	1
DOIs	https://doi.org/10.1128/IAI.69.1.559-563.2001
State	Published - 2001
Externally published	Yes

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10.1128/IAI.69.1.559-563.2001

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title = "Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3)",

abstract = "Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.",

author = "R. DeVinney and I. Nisan and S. Ruschkowski and I. Rosenshine and Finlay, {B. B.}",

year = "2001",

doi = "10.1128/IAI.69.1.559-563.2001",

language = "American English",

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T1 - Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3)

AU - DeVinney, R.

AU - Nisan, I.

AU - Ruschkowski, S.

AU - Rosenshine, I.

AU - Finlay, B. B.

PY - 2001

Y1 - 2001

N2 - Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.

AB - Enteropathogenic Escherichia coli (EPEC) strain 30-5-1(3) has been reported to form attaching and effacing (A/E) lesions without Tir tyrosine phosphorylation. In this study, we show that 30-5-1(3), which has a transposon insertion within the sepZ gene, forms wild-type A/E lesions including Tir tyrosine phosphorylation, but at a slower rate. A/E lesion formation by 30-5-1(3) occurs without detectable secretion of Tir or other EPEC Esp secreted proteins.

UR - http://www.scopus.com/inward/record.url?scp=0035172766&partnerID=8YFLogxK

U2 - 10.1128/IAI.69.1.559-563.2001

DO - 10.1128/IAI.69.1.559-563.2001

M3 - Article

C2 - 11119553

AN - SCOPUS:0035172766

SN - 0019-9567

VL - 69

SP - 559

EP - 563

JO - Infection and Immunity

JF - Infection and Immunity

IS - 1

ER -

Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ::TnphoA mutant 30-5-1(3)

Abstract

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