Tissue microarray-based study of patients with lymph node-positive breast cancer shows tyrosine phosphorylation of signal transducer and activator of transcription 3 (tyrosine705-STAT3) is a marker of good prognosis

Amir Sonnenblick*, Anat Shriki, Eithan Galun, Jonathan H. Axelrod, Hagit Daum, Yakir Rottenberg, Tamar Hamburger, Bela Mali, Tamar Peretz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

Background Although lymph node-positive breast cancers are associated with poorer prognosis, individual patients may have different clinical outcomes. Signal transducer and activator of transcription 3 (STAT3) is a point of convergence for numerous oncogenic signalling pathways. The goal of this study was to determine the prognostic value of phosphorylated (tyrosine705)-STAT3 in node-positive breast cancer patients. Methods Immunohistochemical analysis of Phospho- STAT3 was performed on a tissue microarray of breast cancer specimens. The expression pattern of Phospho-STAT3 was correlated with survival outcome, and clinical and pathological parameters. Results Out of 125 interpretable tumours, positive Phospho- STAT3 nuclear expression was seen in 35 (28%) of tumours. There was no significant relationship between Phospho-STAT3 expression and clinical-pathological parameters including age, hormonal receptor status, grade and tumour size. Interestingly positive tumours had a significantly improved disease-free survival at 5 years (p=0.035). Additionally, positive Phospho-STAT3 nuclear expression was correlated with significantly improved survival at both 5 years (p=0.023) and 10 years (p=0.026). Finally, in multivariate analyses Phospho-STAT3 was found to be an independent prognostic marker of overall survival in node-positive breast cancer patients. Conclusion These findings support the role of Phospho- STAT3 as an important independent prognostic marker in node-positive breast cancer patients.

Original languageAmerican English
Pages (from-to)232-236
Number of pages5
JournalClinical and Translational Oncology
Volume14
Issue number3
DOIs
StatePublished - Mar 2012
Externally publishedYes

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the Sharett Institute of Oncology and Goldyne Savad Institute of Gene Therapy, and partially by grants from Hadassah Medical Center and the American Physicians’ Fellowship (APF) for Medicine in Israel.

Keywords

  • Breast cancer
  • Immunohistochemistry
  • Phosphorylation
  • STAT3
  • Tissue microarray

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