Tissue regeneration potential in human umbilical cord blood

Hadar Arien-Zakay, Philip Lazarovici, Arnon Nagler*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations

Abstract

Regenerative medicine is the process of creating functional tissue with the aid of stem cells, to repair loss of organ function. Possible targets for regenerative medicine include orthopaedic, cardiac, hepatic, pancreatic and central nervous system (CNS) applications. Umbilical cord blood (CB) has established itself as a legitimate source for haematopoietic stem cell transplantation. It is also considered an accessible and less immunogenic source for mesenchymal, unrestricted somatic and for other stem cells with pluri/multipotent properties. The latter are capable of differentiating into a wide variety of cell types including bone, cartilage, cardiomyocytes and neural. They also possess protective abilities that may contribute to tissue repair even if in vitro differentiation is excluded. In view of the absence of treatment for many devastating diseases, the elucidation of non-haematopoietic applications for CB will facilitate the development of pioneering relevant cell therapy approaches. This review focusses on current studies using human CB-derived cells for regenerative medicine.

Original languageAmerican English
Pages (from-to)291-303
Number of pages13
JournalBest Practice and Research: Clinical Haematology
Volume23
Issue number2
DOIs
StatePublished - Jun 2010

Bibliographical note

Funding Information:
The authors would like to thank Prof. Essie Kariv for critical review of the manuscript. HAZ would like to acknowledge the post doctoral fellowship awarded by The Israeli Council for High Education (VATAT). PL would like to acknowledge the financial support from the Israel Ministry of Science and Technology.

Keywords

  • Human umbilical cord blood
  • differentiation
  • mesenchymal and somatic stem cells
  • regenerative potential

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