To break or not to break–context matters

Karin Miron; Batsheva Kerem

doi:10.1080/23723556.2015.1072657

To break or not to break–context matters

Karin Miron, Batsheva Kerem^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

Original language	American English
Article number	e1072657
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1072657
State	Published - 2 Jan 2016

Bibliographical note

Publisher Copyright:
© 2016, © 2016 Taylor & Francis Group, LLC.

Keywords

Cancer breakage
fragile sites
genome instability
oncogene expression
recurrent fragility
replication stress

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1072657

Cite this

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title = "To break or not to break–context matters",

abstract = "Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.",

keywords = "Cancer breakage, fragile sites, genome instability, oncogene expression, recurrent fragility, replication stress",

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AU - Miron, Karin

AU - Kerem, Batsheva

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AB - Oncogene expression can lead to replication stress and genome instability. Recently, we identified oncogene-induced fragile sites (FSs) and revealed that the landscape of recurrent fragility in the same cell type is dynamic. This implies an additional level of complexity in the molecular basis of recurrent fragility in cancer.

KW - Cancer breakage

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KW - genome instability

KW - oncogene expression

KW - recurrent fragility

KW - replication stress

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DO - 10.1080/23723556.2015.1072657

M3 - Article

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To break or not to break–context matters

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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