TY - JOUR
T1 - To cheat or not to cheat
T2 - Tryptophan hydroxylase 2 SNP variants contribute to dishonest behavior
AU - Shen, Qiang
AU - Teo, Meijun
AU - Winter, Eyal
AU - Hart, Einav
AU - Chew, Soo H.
AU - Ebstein, Richard P.
N1 - Publisher Copyright:
© 2016 Shen, Teo, Winter, Hart, Chew and Ebstein.
PY - 2016/5/3
Y1 - 2016/5/3
N2 - Although, lying (bear false witness) is explicitly prohibited in the Decalogue and a focus of interest in philosophy and theology, more recently the behavioral and neural mechanisms of deception are gaining increasing attention from diverse fields especially economics, psychology, and neuroscience. Despite the considerable role of heredity in explaining individual differences in deceptive behavior, few studies have investigated which specific genes contribute to the heterogeneity of lying behavior across individuals. Also, little is known concerning which specific neurotransmitter pathways underlie deception. Toward addressing these two key questions, we implemented a neurogenetic strategy and modeled deception by an incentivized die-under-cup task in a laboratory setting. The results of this exploratory study provide provisional evidence that SNP variants across the tryptophan hydroxylase 2 (TPH2) gene, that encodes the rate-limiting enzyme in the biosynthesis of brain serotonin, contribute to individual differences in deceptive behavior.
AB - Although, lying (bear false witness) is explicitly prohibited in the Decalogue and a focus of interest in philosophy and theology, more recently the behavioral and neural mechanisms of deception are gaining increasing attention from diverse fields especially economics, psychology, and neuroscience. Despite the considerable role of heredity in explaining individual differences in deceptive behavior, few studies have investigated which specific genes contribute to the heterogeneity of lying behavior across individuals. Also, little is known concerning which specific neurotransmitter pathways underlie deception. Toward addressing these two key questions, we implemented a neurogenetic strategy and modeled deception by an incentivized die-under-cup task in a laboratory setting. The results of this exploratory study provide provisional evidence that SNP variants across the tryptophan hydroxylase 2 (TPH2) gene, that encodes the rate-limiting enzyme in the biosynthesis of brain serotonin, contribute to individual differences in deceptive behavior.
KW - Lying
KW - Neurogenetics
KW - Serotonin
KW - Single-nucleotide polymorphism
KW - TPH2
UR - http://www.scopus.com/inward/record.url?scp=84967313928&partnerID=8YFLogxK
U2 - 10.3389/fnbeh.2016.00082
DO - 10.3389/fnbeh.2016.00082
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AN - SCOPUS:84967313928
SN - 1662-5153
VL - 10
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
IS - MAY
M1 - 82
ER -