Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression

Ze'ev Paroush*, S. Mark Wainwright, David Ish-Horowicz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Patterning of the non-segmental termini of the Drosophila embryo depends on signalling via the Torso receptor tyrosine kinase (RTK). Activation of Torso at the poles of the embryo triggers restricted expression of the zygotic gap genes tailless (tll) and huckebein (hkb). In this paper, we show that the Groucho (Gro) corepressor acts in this process to confine terminal gap gene expression to the embryonic termini. Embryos lacking maternal gro activity display ectopic tll and hkb transcription; the former leads, in turn, to lack of abdominal expression of the Kruppel and knirps gap genes. We show that torso signalling permits terminal gap gene expression by antagonising Gro-mediated repression. Thus, the corepressor Gro is employed in diverse developmental contexts and, probably, by a variety of DNA-binding repressors.

Original languageAmerican English
Pages (from-to)3827-3834
Number of pages8
JournalJournal of Embryology and Experimental Morphology
Volume124
Issue number19
StatePublished - 1997

Keywords

  • Drosophila
  • Gap genes
  • Groucho
  • Repression
  • Tailless
  • Terminal patterning
  • Torso signalling

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