Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

Jing Guang; Halen Baker; Orilia Ben-Yishay Nizri; Shimon Firman; Uri Werner-Reiss; Vadim Kapuller; Zvi Israel; Hagai Bergman

doi:10.1038/s41531-021-00211-9

Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

Jing Guang^*, Halen Baker, Orilia Ben-Yishay Nizri, Shimon Firman, Uri Werner-Reiss, Vadim Kapuller, Zvi Israel, Hagai Bergman

^*Corresponding author for this work

Edmond & Lily Safra Center for Brain Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.

Original language	American English
Article number	67
Journal	npj Parkinson's Disease
Volume	7
Issue number	1
DOIs	https://doi.org/10.1038/s41531-021-00211-9
State	Published - Dec 2021

Bibliographical note

Funding Information:
We thank Tamar Ravins-Yaish for assistance with animal care; Atira Bick and ELSC neuroimaging unit (ENU) for assistance with the MRI scan; and Sharon Freeman for general assistance. We thank Anatoly Shapochnikov for help in preparing the experimental setup. This work was supported by grants from the Israel Science Foundation, German Collaborative Research Center TRR295 (Returning dynamic motor network disorders using neuromodulation) Adelis and the Rosetrees Trust (to HBe) and research grant of the department of anesthesiology, Hadassah Medical Center (to SF).

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© 2021, The Author(s).

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title = "Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity",

abstract = "Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson{\textquoteright}s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.",

author = "Jing Guang and Halen Baker and {Ben-Yishay Nizri}, Orilia and Shimon Firman and Uri Werner-Reiss and Vadim Kapuller and Zvi Israel and Hagai Bergman",

note = "Funding Information: We thank Tamar Ravins-Yaish for assistance with animal care; Atira Bick and ELSC neuroimaging unit (ENU) for assistance with the MRI scan; and Sharon Freeman for general assistance. We thank Anatoly Shapochnikov for help in preparing the experimental setup. This work was supported by grants from the Israel Science Foundation, German Collaborative Research Center TRR295 (Returning dynamic motor network disorders using neuromodulation) Adelis and the Rosetrees Trust (to HBe) and research grant of the department of anesthesiology, Hadassah Medical Center (to SF). Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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doi = "10.1038/s41531-021-00211-9",

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AU - Baker, Halen

AU - Ben-Yishay Nizri, Orilia

AU - Firman, Shimon

AU - Werner-Reiss, Uri

AU - Kapuller, Vadim

AU - Israel, Zvi

AU - Bergman, Hagai

N1 - Funding Information: We thank Tamar Ravins-Yaish for assistance with animal care; Atira Bick and ELSC neuroimaging unit (ENU) for assistance with the MRI scan; and Sharon Freeman for general assistance. We thank Anatoly Shapochnikov for help in preparing the experimental setup. This work was supported by grants from the Israel Science Foundation, German Collaborative Research Center TRR295 (Returning dynamic motor network disorders using neuromodulation) Adelis and the Rosetrees Trust (to HBe) and research grant of the department of anesthesiology, Hadassah Medical Center (to SF). Publisher Copyright: © 2021, The Author(s).

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N2 - Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.

AB - Deep brain stimulation (DBS) is currently a standard procedure for advanced Parkinson’s disease. Many centers employ awake physiological navigation and stimulation assessment to optimize DBS localization and outcome. To enable DBS under sedation, asleep DBS, we characterized the cortico-basal ganglia neuronal network of two nonhuman primates under propofol, ketamine, and interleaved propofol-ketamine (IPK) sedation. Further, we compared these sedation states in the healthy and Parkinsonian condition to those of healthy sleep. Ketamine increases high-frequency power and synchronization while propofol increases low-frequency power and synchronization in polysomnography and neuronal activity recordings. Thus, ketamine does not mask the low-frequency oscillations used for physiological navigation toward the basal ganglia DBS targets. The brain spectral state under ketamine and propofol mimicked rapid eye movement (REM) and Non-REM (NREM) sleep activity, respectively, and the IPK protocol resembles the NREM-REM sleep cycle. These promising results are a meaningful step toward asleep DBS with nondistorted physiological navigation.

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Toward asleep DBS: cortico-basal ganglia spectral and coherence activity during interleaved propofol/ketamine sedation mimics NREM/REM sleep activity

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