Toward salivary gland stem cell regeneration.

Raluca Stiubea-Cohen*, Ran David, Yoav Neumann, Aaron Palmon, Doron Aframian

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Head and neck cancer is the sixth most common cancer worldwide, resulting in ~ 640,000 cases. Most of these patients have irreversible damage to their salivary glands due to irradiation therapy, which typically leads to significant decrease in quality of life. In the last 2 decades, several strategies have been suggested to overcome this problem; however, no biologically based treatments are available. In the past few years, the authors of the present article and other researchers have focused on a new strategy of re-implantation of autologous salivary gland cells into the residual irradiated salivary glands. This article reviews the current prospective of the irradiation-induced salivary gland impairment mechanisms and the envisioned therapeutic modalities based on stem cell therapy.

Original languageAmerican English
Pages (from-to)14-17; quiz 18
JournalCompendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
Volume34 Spec No
StatePublished - Jul 2013


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