TY - JOUR
T1 - Toward salivary gland stem cell regeneration.
AU - Stiubea-Cohen, Raluca
AU - David, Ran
AU - Neumann, Yoav
AU - Palmon, Aaron
AU - Aframian, Doron
PY - 2013/7
Y1 - 2013/7
N2 - Head and neck cancer is the sixth most common cancer worldwide, resulting in ~ 640,000 cases. Most of these patients have irreversible damage to their salivary glands due to irradiation therapy, which typically leads to significant decrease in quality of life. In the last 2 decades, several strategies have been suggested to overcome this problem; however, no biologically based treatments are available. In the past few years, the authors of the present article and other researchers have focused on a new strategy of re-implantation of autologous salivary gland cells into the residual irradiated salivary glands. This article reviews the current prospective of the irradiation-induced salivary gland impairment mechanisms and the envisioned therapeutic modalities based on stem cell therapy.
AB - Head and neck cancer is the sixth most common cancer worldwide, resulting in ~ 640,000 cases. Most of these patients have irreversible damage to their salivary glands due to irradiation therapy, which typically leads to significant decrease in quality of life. In the last 2 decades, several strategies have been suggested to overcome this problem; however, no biologically based treatments are available. In the past few years, the authors of the present article and other researchers have focused on a new strategy of re-implantation of autologous salivary gland cells into the residual irradiated salivary glands. This article reviews the current prospective of the irradiation-induced salivary gland impairment mechanisms and the envisioned therapeutic modalities based on stem cell therapy.
UR - http://www.scopus.com/inward/record.url?scp=84906808892&partnerID=8YFLogxK
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C2 - 24568246
AN - SCOPUS:84906808892
SN - 1548-8578
VL - 34 Spec No
SP - 14-17; quiz 18
JO - Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
JF - Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)
ER -