Towards enhancing therapeutic glycoprotein bioproduction: Interventions in the PI3K/AKT/mTOR pathway

Mohamed Mahameed, Afnan Sulieman, Duah Alkam, Boaz Tirosh*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

3 Scopus citations

Abstract

Recombinant glycoproteins produced in mammalian cells are clinically indispensable drugs used to treat a broad spectrum of diseases. Their bio-manufacturing process is laborious, time consuming, and expensive. Investment in expediting the process and reducing its cost is the subject of continued research. The PI3K/Akt/ mTOR signaling pathway is a key regulator of diverse physiological functions such as proliferation, global protein, and lipid synthesis as well as many metabolic pathways interacting to increase secretory capabilities. In this review we detail various strategies previously employed to increase glycoprotein production yields via either genetic or pharmacological over-activation of the PI3K/Akt/mTOR pathway, and we discuss their potential and limitations.

Original languageAmerican English
Pages (from-to)75-83
Number of pages9
JournalCell Structure and Function
Volume44
Issue number2
DOIs
StatePublished - 2019

Bibliographical note

Publisher Copyright:
© 2019 The Author(s).

Keywords

  • CRISPR
  • MTORC1
  • Specific productivity
  • Translation

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