@inproceedings{a57ac18c7ef54e9f99e2d81f93e1e905,
title = "Towards the formation of neuro-transistor artificial chemical synapse",
abstract = "Highly sensitive biosensor for detection of acetylcholine (ACh) and competitive acetylcholinesterase (AChE) inhibitor, eserine, is investigated. Peculiar microelectronic configuration of an ion-sensitive field-effect transistor (ISFET) in addition to a right choice of the pH-transducing nanolayers allows recording a response of the enzyme-modified ISFET (EnFET) to a wide range of ACh concentrations. We demonstrate a remarkable improvement of at least three orders of magnitude in dose response to ACh. Described bioelectronic system reveals clear response, when the catalytic activity of the immobilized AChE is inhibited in a reversible manner by eserine, competitive inhibitor of AChE.",
keywords = "Acetylcholinesterase (AChE), EnFET, Enzyme inhibitor sensing, Neurotransmitter sensing",
author = "I. Goykhman and N. Korbakov and C. Bartic and G. Borghs and Spira, {M. E.} and J. Shappir and S. Yitzchaik",
year = "2007",
doi = "10.1109/SENSOR.2007.4300082",
language = "American English",
isbn = "1424408423",
series = "TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems",
pages = "103--106",
booktitle = "TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems",
note = "4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07 ; Conference date: 10-06-2007 Through 14-06-2007",
}