TY - GEN
T1 - Towards the formation of neuro-transistor artificial chemical synapse
AU - Goykhman, I.
AU - Korbakov, N.
AU - Bartic, C.
AU - Borghs, G.
AU - Spira, M. E.
AU - Shappir, J.
AU - Yitzchaik, S.
PY - 2007
Y1 - 2007
N2 - Highly sensitive biosensor for detection of acetylcholine (ACh) and competitive acetylcholinesterase (AChE) inhibitor, eserine, is investigated. Peculiar microelectronic configuration of an ion-sensitive field-effect transistor (ISFET) in addition to a right choice of the pH-transducing nanolayers allows recording a response of the enzyme-modified ISFET (EnFET) to a wide range of ACh concentrations. We demonstrate a remarkable improvement of at least three orders of magnitude in dose response to ACh. Described bioelectronic system reveals clear response, when the catalytic activity of the immobilized AChE is inhibited in a reversible manner by eserine, competitive inhibitor of AChE.
AB - Highly sensitive biosensor for detection of acetylcholine (ACh) and competitive acetylcholinesterase (AChE) inhibitor, eserine, is investigated. Peculiar microelectronic configuration of an ion-sensitive field-effect transistor (ISFET) in addition to a right choice of the pH-transducing nanolayers allows recording a response of the enzyme-modified ISFET (EnFET) to a wide range of ACh concentrations. We demonstrate a remarkable improvement of at least three orders of magnitude in dose response to ACh. Described bioelectronic system reveals clear response, when the catalytic activity of the immobilized AChE is inhibited in a reversible manner by eserine, competitive inhibitor of AChE.
KW - Acetylcholinesterase (AChE)
KW - EnFET
KW - Enzyme inhibitor sensing
KW - Neurotransmitter sensing
UR - http://www.scopus.com/inward/record.url?scp=50049098601&partnerID=8YFLogxK
U2 - 10.1109/SENSOR.2007.4300082
DO - 10.1109/SENSOR.2007.4300082
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AN - SCOPUS:50049098601
SN - 1424408423
SN - 9781424408429
T3 - TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
SP - 103
EP - 106
BT - TRANSDUCERS and EUROSENSORS '07 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems
T2 - 4th International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS and EUROSENSORS '07
Y2 - 10 June 2007 through 14 June 2007
ER -