TY - JOUR
T1 - Trajectory control of PbSe-γ-Fe2O3 nanoplatforms under viscous flow and an external magnetic field
AU - Etgar, Lioz
AU - Nakhmani, Arie
AU - Tannenbaum, Allen
AU - Lifshitz, Efrat
AU - Tannenbaum, Rina
PY - 2010/4/30
Y1 - 2010/4/30
N2 - The flow behavior of nanostructure clusters, consisting of chemically bonded PbSe quantum dots and magnetic γ-Fe2O3 nanoparticles, has been investigated. The clusters are regarded as model nanoplatforms with multiple functionalities, where the γ-Fe2O3 magnets serve as transport vehicles, manipulated by an external magnetic field gradient, and the quantum dots act as fluorescence tags within an optical window in the near-infrared regime. The clusters' flow was characterized by visualizing their trajectories within a viscous fluid (mimicking a blood stream), using an optical imaging method, while the trajectory pictures were analyzed by a specially developed processing package. The trajectories were examined under various flow rates, viscosities and applied magnetic field strengths. The results revealed a control of the trajectories even at low magnetic fields (<1 T), validating the use of similar nanoplatforms as active targeting constituents in personalized medicine.
AB - The flow behavior of nanostructure clusters, consisting of chemically bonded PbSe quantum dots and magnetic γ-Fe2O3 nanoparticles, has been investigated. The clusters are regarded as model nanoplatforms with multiple functionalities, where the γ-Fe2O3 magnets serve as transport vehicles, manipulated by an external magnetic field gradient, and the quantum dots act as fluorescence tags within an optical window in the near-infrared regime. The clusters' flow was characterized by visualizing their trajectories within a viscous fluid (mimicking a blood stream), using an optical imaging method, while the trajectory pictures were analyzed by a specially developed processing package. The trajectories were examined under various flow rates, viscosities and applied magnetic field strengths. The results revealed a control of the trajectories even at low magnetic fields (<1 T), validating the use of similar nanoplatforms as active targeting constituents in personalized medicine.
UR - http://www.scopus.com/inward/record.url?scp=77954708541&partnerID=8YFLogxK
U2 - 10.1088/0957-4484/21/17/175702
DO - 10.1088/0957-4484/21/17/175702
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 20368678
AN - SCOPUS:77954708541
SN - 0957-4484
VL - 21
JO - Nanotechnology
JF - Nanotechnology
IS - 17
M1 - 175702
ER -