TY - JOUR
T1 - Trans-(4-Methylcyclohexylcarbamoyl)phosphonic acid
T2 - A representative matrix metalloproteinase (MMP) inhibitor
AU - Cohen, Shmuel
AU - Katz, Yiffat
AU - Reich, Reuven
AU - Breuer, Eli
PY - 2005/9/1
Y1 - 2005/9/1
N2 - The title compound, C8H16NO4P, is the first carbamoylphosphonic acid for which the crystal structure has been solved. The -PO3H2 group has three distinct P-O bond distances of 1.483(1), 1.506(1) and 1.545 (2) Å. Hydrogen bonds of types P-O-H⋯O=C and N-H⋯O=P [2.416 (2) and 2.954 (2) Å, respectively] connect the molecules to form a chain of condensed ten-membered hydrogen-bonded rings. The second P-O-H group of each phosphonic acid is hydrogen-bonded to an O=P group of the next chain, so serving to link adjacent chains together.
AB - The title compound, C8H16NO4P, is the first carbamoylphosphonic acid for which the crystal structure has been solved. The -PO3H2 group has three distinct P-O bond distances of 1.483(1), 1.506(1) and 1.545 (2) Å. Hydrogen bonds of types P-O-H⋯O=C and N-H⋯O=P [2.416 (2) and 2.954 (2) Å, respectively] connect the molecules to form a chain of condensed ten-membered hydrogen-bonded rings. The second P-O-H group of each phosphonic acid is hydrogen-bonded to an O=P group of the next chain, so serving to link adjacent chains together.
UR - http://www.scopus.com/inward/record.url?scp=33144480870&partnerID=8YFLogxK
U2 - 10.1107/S1600536805025936
DO - 10.1107/S1600536805025936
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AN - SCOPUS:33144480870
SN - 1600-5368
VL - 61
SP - o3008-o3010
JO - Acta Crystallographica Section E: Structure Reports Online
JF - Acta Crystallographica Section E: Structure Reports Online
IS - 9
ER -