Trans titanium(IV) complexes of salen ligands exhibit high antitumor activity

Avia Tzubery, Edit Y. Tshuva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Salen-titanium(IV) complexes are introduced as a new family of highly efficient antitumor complexes, being the first cytotoxic titanium(IV) complexes of trans labile ligands, as characterized crystallographically. Four complexes with different aromatic substitutions were analyzed, reveling a meaningful effect of the ligand structure on the complex performance. All complexes exhibit high hydrolytic stability, where the labile OAr ligands hydrolyze in a 10% D 2O solution with t 1/2 ranging from 2 to 11 h. The IC 50 values obtained for three of the salen complexes studied on HT-29 colon and OVCAR-1 ovarian cells demonstrate activity that exceeds those of the known tianium(IV) complexes Cp 2TiCl 2 and (bzac) 2Ti(OiPr) 2 and that of cisplatin, where the most active para-chlorinated complex exhibits activity enhancement relative to cisplatin by 10-fold.

Original languageAmerican English
Pages (from-to)7946-7948
Number of pages3
JournalInorganic Chemistry
Volume50
Issue number17
DOIs
StatePublished - 5 Sep 2011

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