Transabdominal amnioinfusion for preterm premature rupture of membranes: A systematic review and metaanalysis of randomized and observational studies

Shay Porat*, Hagai Amsalem, Prakesh S. Shah, Kellie E. Murphy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Objective: The purpose of this study was to review systematically the efficacy of transabdominal amnioinfusion (TA) in early preterm premature rupture of membranes (PPROM). Study Design: We conducted a literature search of EMBASE, MEDLINE, and ClinicalTrials.gov databases and identified studies in which TA was used in cases of proven PPROM and oligohydramnios. Risk of bias was assessed for observational studies and randomized controlled trials. Primary outcomes were latency period and perinatal mortality rates. Results: Four observational studies (n = 147) and 3 randomized controlled trials (n = 165) were eligible. Pooled latency period was 14.4 (range, 8.2-20.6) and 11.41 (range -3.4 to 26.2) days longer in the TA group in the observational and the randomized controlled trials, respectively. Perinatal mortality rates were reduced among the treatment groups in both the observational studies (odds ratio, 0.12; 95% confidence interval, 0.02-0.61) and the randomized controlled trials (odds ratio, 0.33; 95% confidence interval, 0.10-1.12). Conclusion: Serial TA for early PPROM may improve early PPROM-associated morbidity and mortality rates. Additional adequately powered randomized control trials are needed.

Original languageAmerican English
Pages (from-to)393.e1-393.e11
JournalAmerican Journal of Obstetrics and Gynecology
Volume207
Issue number5
DOIs
StatePublished - Nov 2012
Externally publishedYes

Keywords

  • PPROM
  • amnioinfusion
  • latency period
  • oligohydramnios
  • pulmonary hypoplasia

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