Transcleral approach for closing retinal tears using DuraSeal™ hydrogel sealant

Tilda Barliya*, Shai Sandalon, Ron Ofri, Tami Livnat, Dov Weinberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Purpose: The aim of this study was to evaluate an innovative approach for closing retinal tears using DuraSeal™ (DS) hydrogel sealant in a rabbit model. Methods: Retinal detachment with a small tear was performed on 20 New Zealand rabbits. Thereafter, rabbits were divided into two groups; the experimental group received a transscleral injection of 0.1 ml DS into the subretinal space whereas the control group received sham injection of saline. Eyes were clinically evaluated using indirect ophthalmoscopy, retinal function was recorded in ten rabbits by electroretinography and the sealant's toxicity was evaluated histopathologically. Results: We found that the DS hydrogel was easily injected transsclerally into the subretinal space of the detached retinas with no major complications. Retinal reattachment was seen in both groups within 2 weeks with no toxicity to the sensory retina. There were no significant differences in retinal function between groups. Conclusion: Subretinal injection of hydrogel through a transscleral route is easy to perform and may open a new avenue in the treatment of retinal detachment. However, the efficacy of the DS as a tamponade for sealing retinal tear is yet to be definite. Long-term clinical, functional, and toxicological studies are needed to evaluate its full potential for clinical applications.

Original languageAmerican English
Pages (from-to)238-243
Number of pages6
JournalIndian Journal of Ophthalmology
Volume66
Issue number2
DOIs
StatePublished - Feb 2018

Bibliographical note

Publisher Copyright:
© 2018 Indian Journal of Ophthalmology.

Keywords

  • DuraSeal hydrogel sealant
  • retinal detachment
  • retinal tear
  • transcleral approach

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